Frederick W. Goldberg

AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity

Jacqueline H. L. Fok, Antonio Ramos‐Montoya, Mercedes Vázquez–Chantada et al. · Nature Communications · 2019 · 334 citations · Full text

Medicine, Oncology, Radiation Oncology +17

Direct targeting of FOXP3 in Tregs with AZD8701, a novel antisense oligonucleotide to relieve immunosuppression in cancer

Alexey S. Revenko, Larissa S. Carnevalli, Charles Sinclair et al. · Journal for ImmunoTherapy of Cancer · 2022 · 86 citations · Full text

Medicine, Immunology, Oncology +16

Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRAS^G12C

Jason G. Kettle, Sharan K. Bagal, Sue Bickerton et al. · Journal of Medicinal Chemistry · 2020 · 85 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

An Expedient Formal Total Synthesis of (−)-Diazonamide A via a Powerful, Stereoselective <i>O</i>-Aryl to <i>C</i>-Aryl Migration To Form the C10 Quaternary Center

Chi‐Ming Cheung, Frederick W. Goldberg, Philip Magnus et al. · Journal of the American Chemical Society · 2007 · 84 citations · Full text

Natural Sciences, Chemistry, Medicinal Chemistry +11

The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5-<i>a</i>]pyridin-6-yl)amino]-9-(tetrahydro-2<i>H</i>-pyran-4-yl)-7,9-dihydro-8<i>H</i>-purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor

Frederick W. Goldberg, M. Raymond V. Finlay, Attilla Ting et al. · Journal of Medicinal Chemistry · 2019 · 79 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17