Jacqueline H. L. Fok

AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity

Jacqueline H. L. Fok, Antonio Ramos‐Montoya, Mercedes Vázquez–Chantada et al. · Nature Communications · 2019 · 334 citations · Full text

Medicine, Oncology, Radiation Oncology +17

The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models

Stephen T. Durant, Li Zheng, Yingchun Wang et al. · Science Advances · 2018 · 312 citations · Full text

Medicine, Nuclear Medicine, Oncology +17

HSF1 Is Essential for Myeloma Cell Survival and A Promising Therapeutic Target

Jacqueline H. L. Fok, Somaieh Hedayat, Lei Zhang et al. · Clinical Cancer Research · 2018 · 57 citations · Full text

Medicine, Molecular Biology, Oncology +16

Hsp70 inhibition induces myeloma cell death via the intracellular accumulation of immunoglobulin and the generation of proteotoxic stress

Lei Zhang, Jacqueline H. L. Fok, Fabio Mirabella et al. · Cancer Letters · 2013 · 34 citations · Full text

Life Sciences, Molecular Biology, Oncology +17

Radiopotentiation Profiling of Multiple Inhibitors of the DNA Damage Response for Early Clinical Development

Sonja J. Gill, Paul W.G. Wijnhoven, Jacqueline H. L. Fok et al. · Molecular Cancer Therapeutics · 2021 · 22 citations · Full text

Medicine, Oncology, Radiation Oncology +13