Charles Sinclair

Lymphotoxin Signals from Positively Selected Thymocytes Regulate the Terminal Differentiation of Medullary Thymic Epithelial Cells

Andrea J. White, Kyoko Nakamura, William E. Jenkinson et al. · The Journal of Immunology · 2010 · 137 citations · Full text

Lymphocyte Development, Immunology, Immune Regulation +22

mTOR regulates metabolic adaptation of APCs in the lung and controls the outcome of allergic inflammation

Charles Sinclair, Gayathri Bommakanti, Luiz Gustavo Gardinassi et al. · Science · 2017 · 118 citations · Full text

Regulation of <i>Zap70</i> Expression During Thymocyte Development Enables Temporal Separation of CD4 and CD8 Repertoire Selection at Different Signaling Thresholds

Manoj Saini, Charles Sinclair, Daniel Marshall et al. · Science Signaling · 2010 · 95 citations

Lymphocyte Development, Adaptive Immune System, T-regulatory Cell +19

Asymmetric thymocyte death underlies the CD4:CD8 T-cell ratio in the adaptive immune system

Charles Sinclair, Iren Bains, Andrew J. Yates et al. · Proceedings of the National Academy of Sciences · 2013 · 93 citations · Full text

Lymphocyte Development, Adaptive Immune System, T-regulatory Cell +24

PI3Kα/δ inhibition promotes anti-tumor immunity through direct enhancement of effector CD8+ T-cell activity

Larissa S. Carnevalli, Charles Sinclair, Molly A. Taylor et al. · Journal for ImmunoTherapy of Cancer · 2018 · 85 citations · Full text

Pi3k Inhibitors, Immunology, Immune Regulation +24