Attilla Ting

Crystal Structures of Human ADAMTS-1 Reveal a Conserved Catalytic Domain and a Disintegrin-like Domain with a Fold Homologous to Cysteine-Rich Domains

S. Gerhardt, G. Hassall, Paul Hawtin et al. · Journal of Molecular Biology · 2007 · 94 citations

Protein Function, Protein Assembly, Protein Folding +9

The PARP Inhibitor AZD2461 Provides Insights into the Role of PARP3 Inhibition for Both Synthetic Lethality and Tolerability with Chemotherapy in Preclinical Models

Lenka Oplustil O’Connor, Stuart L. Rulten, Aaron Cranston et al. · Cancer Research · 2016 · 90 citations

Chemoprevention Strategy, Parp3 Inhibition, Pharmacotherapy +22

Learning Medicinal Chemistry Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) Rules from Cross-Company Matched Molecular Pairs Analysis (MMPA)

Christian Krämer, Attilla Ting, Hao Zheng et al. · Journal of Medicinal Chemistry · 2017 · 83 citations · Full text

Pharmaceutical Science, Drug Target, Medicinal Chemistry +21

The Discovery of 7-Methyl-2-[(7-methyl[1,2,4]triazolo[1,5-<i>a</i>]pyridin-6-yl)amino]-9-(tetrahydro-2<i>H</i>-pyran-4-yl)-7,9-dihydro-8<i>H</i>-purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor

Frederick W. Goldberg, M. Raymond V. Finlay, Attilla Ting et al. · Journal of Medicinal Chemistry · 2019 · 77 citations · Full text

Pharmacotherapy, Chemical Biology, Dna-pk Catalytic Subunit +20

1-Substituted (Dibenzo[<i>b,d</i>]thiophen-4-yl)-2-morpholino-4<i>H</i>-chromen-4-ones Endowed with Dual DNA-PK/PI3-K Inhibitory Activity

Céline Cano, Kappusamy Saravanan, Chris Bailey et al. · Journal of Medicinal Chemistry · 2013 · 53 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Pharmaceutical Science +14