Lenka Oplustil O’Connor

AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity

Jacqueline H. L. Fok, Antonio Ramos‐Montoya, Mercedes Vázquez–Chantada et al. · Nature Communications · 2019 · 327 citations · Full text

The PARP Inhibitor AZD2461 Provides Insights into the Role of PARP3 Inhibition for Both Synthetic Lethality and Tolerability with Chemotherapy in Preclinical Models

Lenka Oplustil O’Connor, Stuart L. Rulten, Aaron Cranston et al. · Cancer Research · 2016 · 90 citations

Chemoprevention Strategy, Parp3 Inhibition, Pharmacotherapy +22

Tumour-on-chip microfluidic platform for assessment of drug pharmacokinetics and treatment response

Tudor Petreuş, Elaine Cadogan, Gareth Hughes et al. · Communications Biology · 2021 · 56 citations · Full text

Quantifying Drug‐Induced Bone Marrow Toxicity Using a Novel Haematopoiesis Systems Pharmacology Model

Chiara Fornari, Lenka Oplustil O’Connor, Carmen Pin et al. · CPT Pharmacometrics & Systems Pharmacology · 2019 · 20 citations · Full text