Vanessa Rodrik-Outmezguine

AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity

Sarat Chandarlapaty, Ayana Sawai, Maurizio Scaltriti et al. · Cancer Cell · 2011 · 947 citations · Full text

Signal Transduction, Signaling Pathway, Functional Selectivity +8

Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS

Zhan Yao, Rona Yaeger, Vanessa Rodrik-Outmezguine et al. · Nature · 2017 · 540 citations

Oncology, Activated Ras, Class 3 +12

Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor

Vanessa Rodrik-Outmezguine, Masanori Okaniwa, Zhan Yao et al. · Nature · 2016 · 469 citations

Medicine, Mtor Resistance Mutations, Molecular Biology +4

mTOR Kinase Inhibition Causes Feedback-Dependent Biphasic Regulation of AKT Signaling

Vanessa Rodrik-Outmezguine, Sarat Chandarlapaty, Nen C. Pagano et al. · Cancer Discovery · 2011 · 428 citations · Full text

mTORC1 Inhibition Is Required for Sensitivity to PI3K p110α Inhibitors in <i>PIK3CA</i> -Mutant Breast Cancer

Moshe Elkabets, Sadhna Vora, Dejan Juric et al. · Science Translational Medicine · 2013 · 344 citations · Full text