Tumor mutational load predicts survival after immunotherapy across multiple cancer types

Robert Samstein, Chung‐Han Lee, Alexander N. Shoushtari, +54

Nature Genetics

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Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients

Ahmet Zehir, Ryma Benayed, Ronak Shah, +96

Nature Medicine

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OncoKB: A Precision Oncology Knowledge Base

Debyani Chakravarty, Jianjiong Gao, Sarah Phillips, +45

JCO Precision Oncology

Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer

Sandra Misale, Rona Yaeger, Sebastijan Hobor, +23

Nature

Kras MutationsMedicineColorectal CancerPathologyAnti-egfr Therapy +5

PD-1 Blockade in Mismatch Repair–Deficient, Locally Advanced Rectal Cancer

Andrea Cercek, Melissa Lumish, Jenna Sinopoli, +29

New England Journal of Medicine

Encorafenib, Binimetinib, and Cetuximab in <i>BRAF</i> V600E–Mutated Colorectal Cancer

Scott Kopetz, Axel Grothey, Rona Yaeger, +32

New England Journal of Medicine

Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal Cancer

Rona Yaeger, Walid K. Chatila, Marla Lipsyc, +26

Cancer Cell

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Organ Preservation in Patients With Rectal Adenocarcinoma Treated With Total Neoadjuvant Therapy

Julio García‐Aguilar, Sujata Patil, Marc J. Gollub, +39

Journal of Clinical Oncology

Adoption of Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer

Andrea Cercek, Campbell S.D. Roxburgh, Paul Strombom, +20

JAMA Oncology

Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients

Bastien Nguyen, Christopher J. Fong, Anisha Luthra, +71

Cell

UrologyTumor HeterogeneityMedicineNext-generation SequencingPathology +9