Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer

Sandra Misale, Rona Yaeger, Sebastijan Hobor, +23

Nature

Kras MutationsMedicineColorectal CancerPathologyAnti-egfr Therapy +5

Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients

Giulia Siravegna, Benedetta Mussolin, Michela Buscarino, +29

Nature Medicine

MedicinePathologyColorectal CancerColorectal Cancer PatientsEgfr Blockade +4

Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma

Chong Sun, Liqin Wang, Sidong Huang, +22

Nature

PhotocarcinogenesisMelanomaAdaptive ResistanceRadiation OncologyTumor Biology +1

Amplification of the <i>MET</i> Receptor Drives Resistance to Anti-EGFR Therapies in Colorectal Cancer

Alberto Bardelli, Simona Corso, Andrea Bertotti, +25

Cancer Discovery

EngineeringPathologyCancer BiologyTumor BiologyCancer Cell Biology +15

Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal

Samra Turajlic, Hang Xu, Kevin Litchfield, +67

Cell

Intrinsic Resistance to MEK Inhibition in KRAS Mutant Lung and Colon Cancer through Transcriptional Induction of ERBB3

Chong Sun, Sebastijan Hobor, Andrea Bertotti, +18

Cell Reports

Blockade of EGFR and MEK Intercepts Heterogeneous Mechanisms of Acquired Resistance to Anti-EGFR Therapies in Colorectal Cancer

Sandra Misale, Sabrina Arena, Simona Lamba, +14

Science Translational Medicine

Emergence of Multiple <i>EGFR</i> Extracellular Mutations during Cetuximab Treatment in Colorectal Cancer

Sabrina Arena, Beatríz Bellosillo, Giulia Siravegna, +22

Clinical Cancer Research

KRAS gene amplification in colorectal cancer and impact on response to EGFR‐targeted therapy

Emanuele Valtorta, Sandra Misale, Andrea Sartore‐Bianchi, +18

International Journal of Cancer

Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses

Julianna Blagih, Fabio Zani, Probir Chakravarty, +13

Cell Reports