Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens

Fiona M. Behan, Francesco Iorio, Gabriele Picco, +22

Nature

Crispr–cas9 ScreensGene EditingGenome EditingMedicineCell Biology +2

Dual-targeted therapy with trastuzumab and lapatinib in treatment-refractory, KRAS codon 12/13 wild-type, HER2-positive metastatic colorectal cancer (HERACLES): a proof-of-concept, multicentre, open-label, phase 2 trial

Andrea Sartore‐Bianchi, Livio Trusolino, Cosimo Martino, +27

The Lancet Oncology

OncologyMedicinePathologyColorectal CancerDual-targeted Therapy +3

A Molecularly Annotated Platform of Patient-Derived Xenografts (“Xenopatients”) Identifies HER2 as an Effective Therapeutic Target in Cetuximab-Resistant Colorectal Cancer

Andrea Bertotti, Giorgia Migliardi, Francesco Galimi, +25

Cancer Discovery

Amplification of the <i>MET</i> Receptor Drives Resistance to Anti-EGFR Therapies in Colorectal Cancer

Alberto Bardelli, Simona Corso, Andrea Bertotti, +25

Cancer Discovery

EngineeringPathologyCancer BiologyTumor BiologyCancer Cell Biology +15

Stromal contribution to the colorectal cancer transcriptome

Claudio Isella, Andrea Terrasi, Sara E. Bellomo, +15

Nature Genetics

PathologyColorectal CancerColorectal Cancer TranscriptomeCancer GenomicsMedicine +4

The genomic landscape of response to EGFR blockade in colorectal cancer

Andrea Bertotti, Eniko Papp, Siân Jones, +32

Nature

OncologyGenomic LandscapeMedicinePathologyColorectal Cancer +7

EGFR Blockade Reverts Resistance to KRASG12C Inhibition in Colorectal Cancer

Vito Amodio, Rona Yaeger, Pamela Arcella, +26

Cancer Discovery

Effective drug combinations in breast, colon and pancreatic cancer cells

Patricia Jaaks, Elizabeth A. Coker, Daniël J. Vis, +25

Nature

Adaptive mutability of colorectal cancers in response to targeted therapies

Mariangela Russo, Giovanni Crisafulli, Alberto Sogari, +20

Science

PathologyCancer BiologyTumor BiologyDrug ResistanceOncology +14

A Signaling Adapter Function for α6β4 Integrin in the Control of HGF-Dependent Invasive Growth

Livio Trusolino, Andrea Bertotti, Paolo M. Comoglio

Cell

Signal TransductionDevelopmental BiologyHgf-dependent Invasive GrowthSignaling PathwayCell-matrix Interaction +10