Crystal Structure of Human MMP9 in Complex with a Reverse Hydroxamate Inhibitor

Siân Rowsell, Paul Hawtin, Claire A. Minshull, +8

Journal of Molecular Biology

Crystal StructureHuman Mmp9MedicineNatural SciencesMetalloprotein +7

Kinetic and Structural Characteristics of the Inhibition of Enoyl (Acyl Carrier Protein) Reductase by Triclosan

Walter H.J. Ward, Geoffrey A. Holdgate, Siân Rowsell, +13

Biochemistry

Structural CharacteristicsAcyl Carrier ProteinBiochemistryNatural SciencesEnzyme Catalysis +13

Imidazo[1,2-a]pyridines: A potent and selective class of cyclin-Dependent kinase inhibitors identified through structure-Based hybridisation

Malcolm Anderson, John F. Beattie, Gloria A. Breault, +11

Bioorganic & Medicinal Chemistry Letters

Cyclin-dependent Kinase InhibitorsMedicinal ChemistryBioorganic ChemistryHeterocyclicBiochemistry +8

Crystal Structure of Human Thymidine Phosphorylase in Complex with a Small Molecule Inhibitor

Richard A. Norman, Simon T. Barry, Michael Bate, +12

Structure

Crystal StructureBiochemistryNatural SciencesHuman Thymidine PhosphorylaseProtein X-ray Crystallography +6

Crystal Structures of Human ADAMTS-1 Reveal a Conserved Catalytic Domain and a Disintegrin-like Domain with a Fold Homologous to Cysteine-Rich Domains

S. Gerhardt, G. Hassall, Paul Hawtin, +8

Journal of Molecular Biology

Protein FunctionProtein AssemblyProtein FoldingNatural SciencesProtein X-ray Crystallography +7

Crystallographic analysis of triclosan bound to enoyl reductase

Anna Roujeinikova, Colin Levy, Siân Rowsell, +12

Journal of Molecular Biology

BiochemistryStructure ElucidationStructure-function Enzyme KineticsTriclosan BoundCrystallography +1

Cyclin-dependent kinase 4 inhibitors as a treatment for cancer. Part 1: identification and optimisation of substituted 4,6-Bis anilino pyrimidines

John F. Beattie, Gloria A. Breault, Rebecca Ellston, +8

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryCyclin-dependent Kinase 4MedicineNatural SciencesRational Drug Design +7

Structure-based design of protein tyrosine phosphatase-1B inhibitors

Emma Black, J. Breed, Alexander L. Breeze, +13

Bioorganic & Medicinal Chemistry Letters

Drug TargetBiochemistryRational Drug DesignStructure-based Drug DesignStructure-based Design +3

Imidazo[1,2- b ]pyridazines: a potent and selective class of cyclin-dependent kinase inhibitors

Kate F. Byth, Nicola J. Cooper, Janet D. Culshaw, +12

Bioorganic & Medicinal Chemistry Letters

Cyclin-dependent Kinase InhibitorsMedicinal ChemistryBiochemistryNatural SciencesMedicine +10

Cyclin-dependent kinase 4 inhibitors as a treatment for cancer. Part 2: identification and optimisation of substituted 2,4-bis anilino pyrimidines

Gloria A. Breault, Rebecca Ellston, Stephen Green, +7

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryCyclin-dependent Kinase 4MedicineNatural SciencesRational Drug Design +7