Geoffrey A. Holdgate

Epidermal growth factor receptor tyrosine kinase

Walter H.J. Ward, Peter N. Cook, Anthony M. Slater et al. · Biochemical Pharmacology · 1994 · 261 citations

Signal Transduction, Receptor Tyrosine Kinase, Medicine +3

Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530

Tim P. Green, Mike Fennell, Robin Whittaker et al. · Molecular Oncology · 2009 · 254 citations · Full text

The Entropic Penalty of Ordered Water Accounts for Weaker Binding of the Antibiotic Novobiocin to a Resistant Mutant of DNA Gyrase:  A Thermodynamic and Crystallographic Study

Geoffrey A. Holdgate, Alan Riboldi‐Tunnicliffe, Walter H.J. Ward et al. · Biochemistry · 1997 · 206 citations

Molecular Biology, Antibiotic Novobiocin, Water Molecules +19

Design and Synthesis of Novel Lactate Dehydrogenase A Inhibitors by Fragment-Based Lead Generation

Richard A. Ward, C. Brassington, Alexander L. Breeze et al. · Journal of Medicinal Chemistry · 2012 · 169 citations · Full text

Aldo-keto Reductase, Molecular Biology, Lead Identification +19

Kinetic and Structural Characteristics of the Inhibition of Enoyl (Acyl Carrier Protein) Reductase by Triclosan

Walter H.J. Ward, Geoffrey A. Holdgate, Siân Rowsell et al. · Biochemistry · 1999 · 159 citations

Structural Characteristics, Acyl Carrier Protein, Biochemistry +15