Peter N. Cook

Epidermal growth factor receptor tyrosine kinase

Walter H.J. Ward, Peter N. Cook, Anthony M. Slater et al. · Biochemical Pharmacology · 1994 · 261 citations

Signal Transduction, Receptor Tyrosine Kinase, Medicine +3

(2,6-dimethylphenylsulphonyl)nitromethane: A new structural type of aldose reductase inhibitor which follows biphasic kinetics and uses an allosteric binding site

Walter H.J. Ward, Peter N. Cook, Donald J. Mirrlees et al. · Biochemical Pharmacology · 1991 · 17 citations

Medicinal Chemistry, Aldo-keto Reductase, Aldehyde Dehydrogenase +10

Kinetic characteristics of zeneca ZD5522, a potent inhibitor of human and bovine lens aldose reductase

Peter N. Cook, Walter H.J. Ward, J. Mark Petrash et al. · Biochemical Pharmacology · 1995 · 15 citations

Aldo-keto Reductase, Biochemistry, Potent Inhibitor +7

A novel series of non-nucleoside inhibitors of inosine 5′-monophosphate dehydrogenase with immunosuppressive activity§§Abbreviations: β, coefficient of interaction; DTH, delayed-type hypersensitivity; FBS, foetal bovine serum; IMP, inosine 5′-monophosphate; IMPDH, IMP dehydrogenase; K′i, apparent inhibition constant for compound I; Kii, inhibition constant for effect on intercept of Lineweaver–Burk plots; K′x, apparent inhibition constant for compound X; MFT, mycophenolate mofetil; MTT, 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide; MPA, mycophenolic acid; TCA, trichloroacteic acid (10% w/v); v, velocity; v0, uninhibited velocity; and XMP, xanthosine monophosphate.

Trevor J Franklin, William P. Morris, Vivien N. Jacobs et al. · Biochemical Pharmacology · 1999 · 14 citations