Concepedia

(2,6-dimethylphenylsulphonyl)nitromethane: A new structural type of aldose reductase inhibitor which follows biphasic kinetics and uses an allosteric binding site

Walter H.J. Ward, Peter N. Cook, Donald J. Mirrlees, David R. Brittain, John R. Preston, Frank Carey, David P. Tuffin, Ralph Howe

Biochemical Pharmacology · 1991 · 17 citations · 48 references

Concepts

PharmacyChemistryMedicinal ChemistryEnzyme MechanismEnzymologyStructure-activity RelationshipsEnzyme FunctionEnzyme InhibitionEnzyme KineticsEnzyme-substrate RecognitionLigand BindingStructure-activity Relationship AnalysisAldo-keto Reductase CatalysisAldo-keto ReductasesAllosteric BindingAllosteric Binding KineticsAllosteric Binding Site IdentificationAllosteric Ligand BindingEnzyme Inhibitor Synthesis

References

48

The determination of enzyme inhibitor constants

Martin Dixon · Biochemical Journal · 1953 · 4.1K citations · Full text

Life Sciences, Biochemistry, Biochemical Pharmacology +15

[6] Statistical analysis of enzyme kinetic data

W. W. Cleland · Methods in enzymology on CD-ROM/Methods in enzymology · 1979 · 2K citations

Life Sciences, Biochemistry, Biostatistics +12

[17] The kinetics of reversible tight-binding inhibition

Jeffrey W. Williams, John F. Morrison · Methods in enzymology on CD-ROM/Methods in enzymology · 1979 · 692 citations

Life Sciences, Biochemistry, Pharmacology +10

The Aldo-Keto Reductase Superfamily

Kurt M. Bohren, Bryant P. Bullock, Bendicht Wermuth et al. · Journal of Biological Chemistry · 1989 · 453 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +11

Regeneration and Repair of Myelinated Fibers in Sural-Nerve Biopsy Specimens from Patients with Diabetic Neuropathy Treated with Sorbinil

Anders A. F. Sima, Vera Bril, Virgil Nathaniel et al. · New England Journal of Medicine · 1988 · 294 citations

Medicine, Endocrinology, Neurology +12