Concepedia

Allosteric Binding Kinetics

Allosteric Binding Kinetics is a binding kinetics framework that characterizes the time-resolved interaction dynamics between a ligand and its target protein wherein ligand binding at an allosteric site induces conformational changes that modulate the binding affinity and kinetic behavior at a distant orthosteric site.

33

Publications

1.7K

Citations

139

Authors

47

Institutions

Publications per year

2017–2026

3

Parents

Publications

33

A Theoretical Study of the Binding of Small Molecules to a Polymerizing Protein System. A Model for Allosteric Effects<sup>*</sup>

L.W. Nichol, W. J. H. Jackson, Donald J. Winzor · Biochemistry · 1967 · 213 citations

, , +17

A kinetic view of GPCR allostery and biased agonism

J. Robert Lane, Lauren T. May, Robert G. Parton et al. · Nature Chemical Biology · 2017 · 176 citations · Full text

, , +14

Allosteric effects in organic chemistry. Site-specific binding

J. Rebek, John E. Trend, R. V. WATTLEY et al. · Journal of the American Chemical Society · 1979 · 161 citations

, , +16

The allosteric binding of antimycin to cytochrome b in the mitochondrial membrane

J.A. Berden, E.C. Slater · Biochimica et Biophysica Acta (BBA) - Bioenergetics · 1972 · 123 citations

, , +10

Allosteric Binding of Nucleoside Triphosphates to RNA Polymerase Regulates Transcription Elongation

J. E. Foster, Shannon F. Holmes, Dorothy A. Erie · Cell · 2001 · 111 citations · Full text

, , +16

1–5 of 33

Authors

139

  1. LN
    L.W. Nichol

    Australian National University, Australia

    2 publications · 245 citations

    2

    h-index

  2. AC
    Arthur Christopoulos

    Monash University, Australia

    1 publications · 176 citations

    1

    h-index

  3. MB
    Mauricio Báez

    University of Chile, Chile

    1 publications · 32 citations

    1

    h-index

  4. DL
    Dariusz Leszczyński

    Radiation and Nuclear Safety Authority, Finland

    1 publications · 10 citations

    1

    h-index

  5. RJ
    Robert J. Fletterick

    University of California, San Francisco, United States

    1 publications · 51 citations

    1

    h-index

1–5 of 139

Institutions

47

  1. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    2 h-index

    7 publications

    477 citations

  2. Monash University

    Melbourne, Australia

    1 h-index

    4 publications

    704 citations

  3. The University of Queensland

    Brisbane, Australia

    1 h-index

    1 publications

    176 citations

  4. Pfizer (United States)

    New York, United States

    1 h-index

    4 publications

    128 citations

  5. University of Oxford

    Oxford, United Kingdom

    1 h-index

    3 publications

    81 citations

  6. United States Military Academy

    West Point, United States

    1 h-index

    4 publications

    360 citations

  7. Georgetown University Medical Center

    Washington, United States

    1 h-index

    4 publications

    40 citations

  8. Lundbeck (Denmark)

    Copenhagen, Denmark

    1 h-index

    2 publications

    88 citations

1–8 of 47

Venues

  1. Biochemistry

    5 publications · 348 citations

    5

    h-index

  2. Journal of Biological Chemistry

    JBC · 4 publications · 164 citations

    4

    h-index

  3. Journal of the American Chemical Society

    JACS · 2 publications · 251 citations

    2

    h-index

  4. Biophysical Journal

    2 publications · 50 citations

    2

    h-index

  5. European Journal of Biochemistry

    EJB · 2 publications · 48 citations

    2

    h-index

1–5