J. Robert Lane

The 2.6 Angstrom Crystal Structure of a Human A _2A Adenosine Receptor Bound to an Antagonist

Veli‐Pekka Jaakola, Mark T. Griffith, Michael A. Hanson et al. · Science · 2008 · 1.7K citations · Full text

Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs

Ron O. Dror, Hillary F. Green, Céline Valant et al. · Nature · 2013 · 420 citations

Molecular Pharmacology, Drug Target, Biochemistry +11

Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists

Alexander Gillis, Arisbel B. Gondin, Andrea Kliewer et al. · Science Signaling · 2020 · 350 citations · Full text

Biased Agonism, Opioid Epidemic, Pain Medicine +23

The role of kinetic context in apparent biased agonism at GPCRs

Carmen Klein Herenbrink, David A. Sykes, Prashant Donthamsetti et al. · Nature Communications · 2016 · 330 citations · Full text

Structure-Based Discovery of Novel Chemotypes for Adenosine A_2AReceptor Antagonists

Vsevolod Katritch, Veli‐Pekka Jaakola, J. Robert Lane et al. · Journal of Medicinal Chemistry · 2010 · 240 citations · Full text