Alexander L. Breeze

Isotope-filtered NMR methods for the study of biomolecular structure and interactions

Alexander L. Breeze · Progress in Nuclear Magnetic Resonance Spectroscopy · 2000 · 201 citations

Biochemistry, Magnetic Resonance Spectroscopy, Natural Sciences +9

Design and Synthesis of Novel Lactate Dehydrogenase A Inhibitors by Fragment-Based Lead Generation

Richard A. Ward, C. Brassington, Alexander L. Breeze et al. · Journal of Medicinal Chemistry · 2012 · 169 citations · Full text

Aldo-keto Reductase, Molecular Biology, Lead Identification +19

Structure of an SH2 domain of the p85α subunit of phosphatidylinositol-3-OH kinase

Grant W. Booker, Alexander L. Breeze, A. Kristina Downing et al. · Nature · 1992 · 167 citations

Protein Function, Signal Transduction, Molecular Physiology +12

The high-resolution crystal structure of a 24-kDa gyrase B fragment fromE. coli complexed with one of the most potent coumarin inhibitors, clorobiocin

Francis Tsai, Onkar Singh, Tadeusz Skarżyński et al. · Proteins Structure Function and Bioinformatics · 1997 · 150 citations

Coumarin Antibiotics, Crystal Structure, High-resolution Crystal Structure +15

Pyrrolamide DNA Gyrase Inhibitors: Fragment-Based Nuclear Magnetic Resonance Screening To Identify Antibacterial Agents

Ann E. Eakin, Oluyinka Green, Neil J. Hales et al. · Antimicrobial Agents and Chemotherapy · 2011 · 132 citations

Essential Enzyme, Lead Identification, Antimicrobial Chemotherapy +18