Tadeusz Skarżyński

The nature of inhibition of DNA gyrase by the coumarins and the cyclothialidines revealed by X‐ray crystallography.

Richard J. Lewis, Okram Mukherjee Singh, Clare V. Smith et al. · The EMBO Journal · 1996 · 331 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +5

Structure of UDP-N-acetylglucosamine enolpyruvyl transferase, an enzyme essential for the synthesis of bacterial peptidoglycan, complexed with substrate UDP-N-acetylglucosamine and the drug fosfomycin

Tadeusz Skarżyński, Anil Mistry, Alan J. Wonacott et al. · Structure · 1996 · 264 citations · Full text

Life Sciences, Biochemistry, Microbiology +15

Structure of full-length porcine synovial collagenase reveals a C-terminal domain containing a calcium-linked, four-bladed β-propeller

Jing Li, P. Brick, MC O'Hare et al. · Structure · 1995 · 260 citations · Full text

Life Sciences, Biophysics, Molecular Biology +12

Dihydropyrancarboxamides Related to Zanamivir:  A New Series of Inhibitors of Influenza Virus Sialidases. 2. Crystallographic and Molecular Modeling Study of Complexes of 4-Amino-4<i>H</i>-pyran-6-carboxamides and Sialidase from Influenza Virus Types A and B

Neil R. Taylor, Anne Cleasby, Onkar Singh et al. · Journal of Medicinal Chemistry · 1998 · 193 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

The high-resolution crystal structure of a 24-kDa gyrase B fragment fromE. coli complexed with one of the most potent coumarin inhibitors, clorobiocin

Francis Tsai, Onkar Singh, Tadeusz Skarżyński et al. · Proteins Structure Function and Bioinformatics · 1997 · 150 citations

Life Sciences, Biochemistry, Molecular Biology +10