Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules

Xiayang Qiu, Anil Mistry, Mark Ammirati, +23

Nature Structural & Molecular Biology

Crystal StructureProteinlipid InteractionLong TunnelBiochemistryNatural Sciences +5

Structure of UDP-N-acetylglucosamine enolpyruvyl transferase, an enzyme essential for the synthesis of bacterial peptidoglycan, complexed with substrate UDP-N-acetylglucosamine and the drug fosfomycin

Tadeusz Skarżyński, Anil Mistry, Alan J. Wonacott, +3

Structure

BiosynthesisBiochemistryUdp-n-acetylglucosamine Enolpyruvyl TransferaseNatural SciencesBiocatalysis +9

Kinetic and Structural Characteristics of the Inhibition of Enoyl (Acyl Carrier Protein) Reductase by Triclosan

Walter H.J. Ward, Geoffrey A. Holdgate, Siân Rowsell, +13

Biochemistry

Structural CharacteristicsAcyl Carrier ProteinBiochemistryNatural SciencesEnzyme Catalysis +13

Crystal structure of the anti-fungal target N-myristoyl transferase

Simon A. Weston, Roger Camble, Jeremy G. Colls, +11

Nature Structural Biology

Crystal StructureFungal Cell BiologyBiochemistry

Structural Characterization of Proline-rich Tyrosine Kinase 2 (PYK2) Reveals a Unique (DFG-out) Conformation and Enables Inhibitor Design

Seungil Han, Anil Mistry, Jeanne S. Chang, +9

Journal of Biological Chemistry

Crystallographic analysis of triclosan bound to enoyl reductase

Anna Roujeinikova, Colin Levy, Siân Rowsell, +12

Journal of Molecular Biology

BiochemistryStructure ElucidationStructure-function Enzyme KineticsTriclosan BoundCrystallography +1

Sulfoximine-substituted trifluoromethylpyrimidine analogs as inhibitors of proline-rich tyrosine kinase 2 (PYK2) show reduced hERG activity

Daniel P. Walker, Michael P. Zawistoski, Molly A. McGlynn, +10

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPharmaceutical ChemistrySignal TransductionBiochemistryMedicine +9

Crystal Structures of Cholesteryl Ester Transfer Protein in Complex with Inhibitors

Shenping Liu, Anil Mistry, Jennifer M. Reynolds, +6

Journal of Biological Chemistry

Characterization of the active site of S. aureus monofunctional glycosyltransferase (Mtg) by site-directed mutation and structural analysis of the protein complexed with moenomycin

H. Heaslet, Bailin Shaw, Anil Mistry, +1

Journal of Structural Biology

Site-directed MutationBiochemistryNatural SciencesGlycobiologyMolecular Biology +6

Trifluoromethylpyrimidine-based inhibitors of proline-rich tyrosine kinase 2 (PYK2): Structure–activity relationships and strategies for the elimination of reactive metabolite formation

Daniel P. Walker, F. Christopher Bi, Amit S. Kalgutkar, +25

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryBiochemistryMedicineNatural Sciences +7