AZD1152, a Selective Inhibitor of Aurora B Kinase, Inhibits Human Tumor Xenograft Growth by Inducing Apoptosis

Robert W. Wilkinson, Rajesh Odedra, Simon P. Heaton, +16

Clinical Cancer Research

Discovery, Synthesis, and <i>in Vivo</i> Activity of a New Class of Pyrazoloquinazolines as Selective Inhibitors of Aurora B Kinase

Andrew Mortlock, Kevin M. Foote, Nicola M. Heron, +28

Journal of Medicinal Chemistry

Pharmaceutical ScienceSelective InhibitorsPharmacotherapyAurora BChemical Biology +15

SAR and inhibitor complex structure determination of a novel class of potent and specific Aurora kinase inhibitors

Nicola M. Heron, Malcolm Anderson, David P. Blowers, +13

Bioorganic & Medicinal Chemistry Letters

Molecular DockingMedicineNatural SciencesReceptor Tyrosine KinaseRational Drug Design +7

Catalytic and Enantioselective Route to Medium-Ring Heterocycles. Asymmetric Zirconium-Catalyzed Ethylmagnesation of Seven- and Eight-Membered Rings

Michael Visser, Nicola M. Heron, Mary T. Didiuk, +2

Journal of the American Chemical Society

Eight-membered RingsChemical EngineeringEngineeringAlkene MetathesisKinetic Resolution +13

Discovery of Novel and Potent Thiazoloquinazolines as Selective Aurora A and B Kinase Inhibitors

Frédéric Jung, Georges Pasquet, Christine Lambert‐van der Brempt, +20

Journal of Medicinal Chemistry

Planar ConformationPharmacotherapySelective Aurora AHeterocycle ChemistryChemical Biology +17

Ni-Catalyzed Asymmetric Addition of Grignard Reagents to Unsaturated Cyclic Acetals. The Influence of Added Phosphine on Enantioselectivity

Enrique Gómez‐Bengoa, Nicola M. Heron, Mary T. Didiuk, +2

Journal of the American Chemical Society

Chemical EngineeringEngineeringGrignard ReagentsAltmetric Attention ScoreOrganic Chemistry +7

Discovery of an Orally Bioavailable NK1 Receptor Antagonist, (2S,3S)-(2-Methoxy-5-tetrazol-1-ylbenzyl)(2-phenylpiperidin-3-yl)amine (GR203040), with Potent Antiemetic Activity

P. Ward, Duncan Armour, David E. Bays, +6

Journal of Medicinal Chemistry

Potent Antiemetic ActivityMedicinal ChemistryMethyl SulfoneMetabolic ProfilePharmacological Study +12

Stereoselective Heteroatom-Assisted Allylic Alkylation of Cyclic Ethers with Grignard Reagents. A Convenient Route to Enantiomerically Pure Carbocycles

Nicola M. Heron, Jeffrey A. Adams, Amir H. Hoveyda

Journal of the American Chemical Society

Asymmetric CatalysisCross-coupling ReactionEngineeringHeterocyclicGrignard Reagents +8

(1<i>R</i>,2<i>R</i>)-<i>N</i>-(1-Cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-<i>b</i>]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): A Potent and Highly Selective Cathepsin K Inhibitor for the Treatment of Osteoarthritis

Alexander G. Dossetter, Howard A. Beeley, Jonathan Bowyer, +22

Journal of Medicinal Chemistry

Combinatorial ChemistryPharmaceutical ScienceBioorganic ChemistryPharmacotherapyChemical Biology +17

Evaluating a novel cervical orthosis, the Sheffield Support Snood, in patients with amyotrophic lateral sclerosis/motor neuron disease with neck weakness

Susan Baxter, Heath Reed, Zoë Clarke, +11

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

New DeviceNeurological DisorderChiropracticNeck DisorderSheffield Support Snood +22