Georges Pasquet

Discovery, Synthesis, and <i>in Vivo</i> Activity of a New Class of Pyrazoloquinazolines as Selective Inhibitors of Aurora B Kinase

Andrew Mortlock, Kevin M. Foote, Nicola M. Heron et al. · Journal of Medicinal Chemistry · 2007 · 274 citations · Full text

Medicine, Oncology, Pharmacology +13

Discovery of Novel and Potent Thiazoloquinazolines as Selective Aurora A and B Kinase Inhibitors

Frédéric Jung, Georges Pasquet, Christine Lambert‐van der Brempt et al. · Journal of Medicinal Chemistry · 2006 · 92 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases

Patrick A. Plé, Frédéric Jung, Sue Ashton et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 48 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Discovery of 1-(4-(5-(5-amino-6-(5-tert-butyl-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one (AZD8835): A potent and selective inhibitor of PI3Kα and PI3Kδ for the treatment of cancers

Bernard Barlaam, Sabina Cosulich, Bénédicte Delouvrié et al. · Bioorganic & Medicinal Chemistry Letters · 2015 · 35 citations

Medicine, Medicinal Chemistry, Pharmacology +8

Synthesis and SAR of 1-acetanilide-4-aminopyrazole-substituted quinazolines: Selective inhibitors of Aurora B kinase with potent anti-tumor activity

Kevin M. Foote, Andrew Mortlock, Nicola M. Heron et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 34 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14