Concepedia

Synthesis and SAR of 1-acetanilide-4-aminopyrazole-substituted quinazolines: Selective inhibitors of Aurora B kinase with potent anti-tumor activity

Kevin M. Foote, Andrew Mortlock, Nicola M. Heron, Frédéric Jung, George B. Hill, Georges Pasquet, Madeleine C. Brady, Stephen Green, Simon P. Heaton, Sarah Kearney,

Bioorganic & Medicinal Chemistry Letters · 2008 · 34 citations · 11 references

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11

Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

Claire Ditchfield, Victoria Johnson, Anthony Tighe et al. · The Journal of Cell Biology · 2003 · 1.2K citations · Full text

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VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo

Elizabeth A. Harrington, David Bebbington, Jeffrey R. Moore et al. · Nature Medicine · 2004 · 954 citations · Full text

, , +13

Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase

Mark Manfredi, Jeffrey Ecsedy, Kristan Meetze et al. · Proceedings of the National Academy of Sciences · 2007 · 413 citations · Full text

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AZD1152, a Selective Inhibitor of Aurora B Kinase, Inhibits Human Tumor Xenograft Growth by Inducing Apoptosis

Robert W. Wilkinson, Rajesh Odedra, Simon P. Heaton et al. · Clinical Cancer Research · 2007 · 357 citations · Full text

, , +16

Validating Aurora B as an anti-cancer drug target

Fiona Girdler, Karen E. Gascoigne, Patrick A. Eyers et al. · Journal of Cell Science · 2006 · 283 citations · Full text

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