George B. Hill

Discovery of a Potent and Selective EGFR Inhibitor (AZD9291) of Both Sensitizing and T790M Resistance Mutations That Spares the Wild Type Form of the Receptor

M. Raymond V. Finlay, Mark J. Anderton, Susan Ashton et al. · Journal of Medicinal Chemistry · 2014 · 602 citations · Full text

Medicine, Oncology, Pharmacology +15

Discovery, Synthesis, and <i>in Vivo</i> Activity of a New Class of Pyrazoloquinazolines as Selective Inhibitors of Aurora B Kinase

Andrew Mortlock, Kevin M. Foote, Nicola M. Heron et al. · Journal of Medicinal Chemistry · 2007 · 274 citations · Full text

Medicine, Oncology, Pharmacology +13

Structure- and Reactivity-Based Development of Covalent Inhibitors of the Activating and Gatekeeper Mutant Forms of the Epidermal Growth Factor Receptor (EGFR)

Richard A. Ward, Mark J. Anderton, Susan Ashton et al. · Journal of Medicinal Chemistry · 2013 · 261 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

SAR and inhibitor complex structure determination of a novel class of potent and specific Aurora kinase inhibitors

Nicola M. Heron, Malcolm Anderson, David P. Blowers et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 125 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +16

Novel inhibitors of prolyl 4-hydroxylase. 3. Inhibition by the substrate analog N-oxaloglycine and its derivatives

C. Jane Cunliffe, Trevor Franklin, Neil J. Hales et al. · Journal of Medicinal Chemistry · 1992 · 95 citations · Full text

Life Sciences, Biochemistry, Pharmacology +11