Simon P. Heaton

First-in-Man Clinical Trial of the Oral Pan-AKT Inhibitor MK-2206 in Patients With Advanced Solid Tumors

Timothy A. Yap, Yan Li, Amita Patnaik et al. · Journal of Clinical Oncology · 2011 · 543 citations

Medicine, Oncology, Pharmacology +17

AZD1152, a Selective Inhibitor of Aurora B Kinase, Inhibits Human Tumor Xenograft Growth by Inducing Apoptosis

Robert W. Wilkinson, Rajesh Odedra, Simon P. Heaton et al. · Clinical Cancer Research · 2007 · 357 citations · Full text

Medicine, Oncology, Pharmacology +16

Discovery, Synthesis, and <i>in Vivo</i> Activity of a New Class of Pyrazoloquinazolines as Selective Inhibitors of Aurora B Kinase

Andrew Mortlock, Kevin M. Foote, Nicola M. Heron et al. · Journal of Medicinal Chemistry · 2007 · 274 citations · Full text

Medicine, Oncology, Pharmacology +13

The MEK1/2 inhibitor, selumetinib (AZD6244; ARRY-142886), enhances anti-tumour efficacy when combined with conventional chemotherapeutic agents in human tumour xenograft models

Sarah V. Holt, Armelle Logié, Rajesh Odedra et al. · British Journal of Cancer · 2012 · 111 citations · Full text

Medicine, Oncology, Pharmacology +16

Discovery of Novel and Potent Thiazoloquinazolines as Selective Aurora A and B Kinase Inhibitors

Frédéric Jung, Georges Pasquet, Christine Lambert‐van der Brempt et al. · Journal of Medicinal Chemistry · 2006 · 92 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17