Michael S. Bodnarchuk

Author

AstraZeneca (United Kingdom)ORCID

Also Known As

M Bodnarchuk, M. S. Bodnarchuk, M.S. Bodnarchuk, Michael Bodnarchuk, Michael S. Bodnarchuk, Michael Steven Bodnarchuk

Publications

990

Citations

H-Index

Concepts

All Affiliations

AstraZeneca (United Kingdom)University of Southampton AstraZeneca (United States)AstraZeneca (Singapore)Syngenta (United Kingdom)

About

Michael S. Bodnarchuk is an author at AstraZeneca (United Kingdom) specializing in engineering, biophysics, and computational chemistry.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Engineering	7	7	283
2	Natural Sciences	6	6	210
3	Medicine	4	4	97
4	Biochemistry	4	4	220
5	Biomolecular Engineering	2	2	38

Michael S. Bodnarchuk

Publications

859

Citations

H-Index

Page 1

	Year	Citations
Water Sites, Networks, And Free Energies with Grand Canonical Monte Carlo Gregory A. Ross, Michael S. Bodnarchuk, Jonathan W. Essex Journal of the American Chemical Society EngineeringWater SitesComputational ChemistryWater MoleculesMolecular Design	2015	130
Water Network Perturbation in Ligand Binding: Adenosine A<sub>2A</sub>Antagonists as a Case Study Andrea Bortolato, B.G. Tehan, Michael S. Bodnarchuk, Journal of Chemical Information and Modeling	2013	117
Lowering Lipophilicity by Adding Carbon: One-Carbon Bridges of Morpholines and Piperazines Sébastien L. Degorce, Michael S. Bodnarchuk, Iain Cumming, Journal of Medicinal Chemistry	2018	86
Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRAS<sup>G12C</sup> Jason G. Kettle, Sharan K. Bagal, Sue Bickerton, Journal of Medicinal Chemistry	2020	80
Alkynyl Benzoxazines and Dihydroquinazolines as Cysteine Targeting Covalent Warheads and Their Application in Identification of Selective Irreversible Kinase Inhibitors Kirsten McAulay, Emily Hoyt, Morgan Thomas, Journal of the American Chemical Society	2020	73
Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRAS<sup>G12C</sup> Jason G. Kettle, Sharan K. Bagal, Sue Bickerton, Journal of Medicinal Chemistry	2022	56
Lowering Lipophilicity by Adding Carbon: AzaSpiroHeptanes, a log<i>D</i> Lowering Twist Sébastien L. Degorce, Michael S. Bodnarchuk, James S. Scott ACS Medicinal Chemistry Letters	2019	53
Strategies to Calculate Water Binding Free Energies in Protein–Ligand Complexes Michael S. Bodnarchuk, Russell Viner, Julien Michel, Journal of Chemical Information and Modeling Protein ChemistryEngineeringBiochemistryProtein FoldingBound Water Molecules	2014	51
Sensitivity of Binding Free Energy Calculations to Initial Protein Crystal Structure Miroslav Suruzhon, Michael S. Bodnarchuk, Antonella Ciancetta, Journal of Chemical Theory and Computation EngineeringProtein AssemblyMolecular BiologyComputational ChemistryMolecular Dynamics	2021	28
Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRAS<sup>G12C</sup> with Demonstrable CNS Penetration Jason G. Kettle, Sharan K. Bagal, Derek Barratt, Journal of Medicinal Chemistry	2023	27

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