Concepedia

Pyrazolopyridines as a novel structural class of potent and selective PDE4 inhibitors

J. Hamblin, Tony D. Angell, Stuart P. Ballantine, Caroline M. Cook, John A. Dawson, C. J. Delves, Paul S. Jones, Mika Lindvall, Fiona S. Lucas, Charlotte Mitchell,

Bioorganic & Medicinal Chemistry Letters · 2008 · 71 citations · 6 references

DOIFull text

Open access

Concepts

References

6

In Vivo Efficacy in Airway Disease Models of Roflumilast, a Novel Orally Active PDE4 Inhibitor

Daniela S. Bundschuh, Manfrid Eltze, Johannes Barsig et al. · Journal of Pharmacology and Experimental Therapeutics · 2001 · 239 citations

, , +16

Phosphodiesterase 4B2 Is the Predominant Phosphodiesterase Species and Undergoes Differential Regulation of Gene Expression in Human Monocytes and Neutrophils

Peng Wang, Ping Wu, Kathleen M. Ohleth et al. · Molecular Pharmacology · 1999 · 169 citations

, , +16

Identification, characterization and functional role of phosphodiesterase isozymes in human airway smooth muscle.

Theodore J. Torphy, Bradley J. Undem, L B Cieslinski et al. · Journal of Pharmacology and Experimental Therapeutics · 1993 · 165 citations

, , +14

Synthesis and structure-activity relationships of a series of anxioselective pyrazolopyridine ester and amide anxiolytic agents

Thomas M. Bare, Judy W. Firor, James F. Resch et al. · Journal of Medicinal Chemistry · 1989 · 106 citations

, , +14

Substituted Pyrazolopyridines as Potent and Selective PDE5 Inhibitors:  Potential Agents for Treatment of Erectile Dysfunction

Guixue Yu, Helen J. Mason, Ximao Wu et al. · Journal of Medicinal Chemistry · 2001 · 45 citations · Full text

, , +17