Discovery of a potent and selective series of pyrazole bacterial methionyl-tRNA synthetase inhibitors

John Finn, Karen Mattia, Mike Morytko, +6

Bioorganic & Medicinal Chemistry Letters

BiochemistryNatural SciencesMedicineRational Drug DesignAntibacterial Agent +7

Discovery of Tyrosine-Based Potent and Selective Melanocortin-1 Receptor Small-Molecule Agonists with Anti-inflammatory Properties

Timothy F. Herpin, Guixue Yu, Kenneth E. Carlson, +8

Journal of Medicinal Chemistry

ImmunologyDermatologySkin PigmentationCompound 2Inflammation +14

Substituted Pyrazolopyridines as Potent and Selective PDE5 Inhibitors:  Potential Agents for Treatment of Erectile Dysfunction

Guixue Yu, Helen J. Mason, Ximao Wu, +11

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryUrologyCardiovascular Drug DiscoveryTranslational Pharmacology +12

A selective small molecule agonist of the melanocortin-1 receptor inhibits lipopolysaccharide-induced cytokine accumulation and leukocyte infiltration in mice

Liya Kang, Kim W. McIntyre, Kathleen M. Gillooly, +15

Journal of Leukocyte Biology

Lung InflammationImmunologyImmune RegulationInflammationMolecular Pharmacology +14

Substituted Pyrazolopyridopyridazines as Orally Bioavailable Potent and Selective PDE5 Inhibitors:  Potential Agents for Treatment of Erectile Dysfunction

Guixue Yu, Helen J. Mason, Ximao Wu, +14

Journal of Medicinal Chemistry

Medicinal ChemistryUrologyOrally Bioavailable PotentSelective Pde5 InhibitorsErectile Dysfunction +8

Discovery of Pyrrolidine-Containing GPR40 Agonists: Stereochemistry Effects a Change in Binding Mode

Elizabeth A. Jurica, Ximao Wu, Kristin N. Williams, +35

Journal of Medicinal Chemistry

Synthesis of fused pyridopyrrolidine dione derivatives using hetero Diels–Alder reactions

Helen J. Mason, Ximao Wu, Rebecca Schmitt, +2

Tetrahedron Letters

EngineeringHeterocyclicOrganic ChemistryHetero Diels–alder ReactionsChemistry +4

Discovery of Potent and Orally Bioavailable Dihydropyrazole GPR40 Agonists

Jun Shi, Zhengxiang Gu, Elizabeth A. Jurica, +36

Journal of Medicinal Chemistry

Synthesis of triazolopyridines and triazolopyrimidines using a modified Mitsunobu reaction

Jacques Y. Roberge, Guixue Yu, Amarendra B. Mikkilineni, +4

ARKIVOC

HeterocyclicMitsunobu ReactionNatural SciencesDiversity-oriented SynthesisMild Conditions +5

A mild and efficient method for aromatic chlorination of electron-rich arylalkyl amines

Guixue Yu, Helen J. Mason, Ximao Wu, +3

Tetrahedron Letters

Chemical EngineeringEngineeringEfficient MethodElectron-rich Arylalkyl AminesOrganic Chemistry +3