Kathleen M. Gillooly

2-Aminothiazole as a Novel Kinase Inhibitor Template. Structure−Activity Relationship Studies toward the Discovery of <i>N</i> -(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (Dasatinib, BMS-354825) as a Potent <i>pan</i> -Src Kinase Inhibitor

Jagabandhu Das, Ping Chen, Derek Norris et al. · Journal of Medicinal Chemistry · 2006 · 400 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165

Stephen T. Wrobleski, Ryan Moslin, Shuqun Lin et al. · Journal of Medicinal Chemistry · 2019 · 369 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Autoimmune pathways in mice and humans are blocked by pharmacological stabilization of the TYK2 pseudokinase domain

James R. Burke, Lihong Cheng, Kathleen M. Gillooly et al. · Science Translational Medicine · 2019 · 282 citations

Life Sciences, Immunology, Pharmacology +14

A highly selective inhibitor of IκB kinase, BMS‐345541, blocks both joint inflammation and destruction in collagen‐induced arthritis in mice

Kim W. McIntyre, David J. Shuster, Kathleen M. Gillooly et al. · Arthritis & Rheumatism · 2003 · 218 citations

Medicine, Immunology, Pharmacology +17

Reduced incidence and severity of collagen‐induced arthritis in interleukin‐12‐deficient mice

Kim W. McIntyre, David J. Shuster, Kathleen M. Gillooly et al. · European Journal of Immunology · 1996 · 176 citations

Medicine, Immunology, Pathology +15