David J. Shuster

2-Aminothiazole as a Novel Kinase Inhibitor Template. Structure−Activity Relationship Studies toward the Discovery of <i>N</i> -(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (Dasatinib, BMS-354825) as a Potent <i>pan</i> -Src Kinase Inhibitor

Jagabandhu Das, Ping Chen, Derek Norris et al. · Journal of Medicinal Chemistry · 2006 · 400 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Characterization of E-selectin-deficient mice: Demonstration of overlapping function of the endothelial selectins

Mark Labow, Christine R. Norton, John M. Rumberger et al. · Immunity · 1994 · 381 citations

Life Sciences, Molecular Biology, Physiology +10

Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165

Stephen T. Wrobleski, Ryan Moslin, Shuqun Lin et al. · Journal of Medicinal Chemistry · 2019 · 369 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Absence of IL-1 signaling and reduced inflammatory response in IL-1 type I receptor-deficient mice

Mark Labow, David J. Shuster, Maria Zetterström et al. · The Journal of Immunology · 1997 · 331 citations

Veterinary Medicine, Immunology, Pathology +15

A highly selective inhibitor of IκB kinase, BMS‐345541, blocks both joint inflammation and destruction in collagen‐induced arthritis in mice

Kim W. McIntyre, David J. Shuster, Kathleen M. Gillooly et al. · Arthritis & Rheumatism · 2003 · 218 citations

Medicine, Immunology, Pharmacology +17