James R. Burke

BMS-345541 Is a Highly Selective Inhibitor of IκB Kinase That Binds at an Allosteric Site of the Enzyme and Blocks NF-κB-dependent Transcription in Mice

James R. Burke, Mark A. Pattoli, Kurt R. Gregor et al. · Journal of Biological Chemistry · 2003 · 532 citations · Full text

Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165

Stephen T. Wrobleski, Ryan Moslin, Shuqun Lin et al. · Journal of Medicinal Chemistry · 2019 · 345 citations · Full text

Autoimmune pathways in mice and humans are blocked by pharmacological stabilization of the TYK2 pseudokinase domain

James R. Burke, Lihong Cheng, Kathleen M. Gillooly et al. · Science Translational Medicine · 2019 · 268 citations

IKK mediates ischemia-induced neuronal death

Oliver Herrmann, Bernd Baumann, Rossana De Lorenzi et al. · Nature Medicine · 2005 · 259 citations

Molecular Neuroscience, Neurophysiology, Ischemia-induced Neuronal Death +10

Duration and Intensity of NF-κB Activity Determine the Severity of Endotoxin-Induced Acute Lung Injury

M. Brett Everhart, Wei Han, Taylor P. Sherrill et al. · The Journal of Immunology · 2006 · 230 citations

Acute Lung Injury, Inflammatory Lung Disease, Lung Inflammation +21