James R. Burke - Concepedia

Author

James R. Burke

Bristol-Myers Squibb (United States)ORCID

Also Known As

Burke, James R., J. Burke, J. R. BURKE, J. R. Burke, J.R. Burke, JAMES R. BURKE, James Burke, James R Burke, James R. Burke, James R. Burke

Publications

4.1K

Citations

H-Index

Concepts

All Affiliations

Bristol-Myers Squibb (United States)Bristol-Myers Squibb (Germany)

About

James R. Burke is an author at Bristol-Myers Squibb (United States) specializing in medicine, natural sciences, and pharmacology.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	18	24	1.4K
2	Natural Sciences	14	16	478
3	Engineering	3	3	85
4	Social Sciences	1	1	259
5	Allergy	1	1	21

James R. Burke

Publications

Citations

H-Index

Page 1

	Year	Citations
BMS-345541 Is a Highly Selective Inhibitor of IκB Kinase That Binds at an Allosteric Site of the Enzyme and Blocks NF-κB-dependent Transcription in Mice James R. Burke, Mark A. Pattoli, Kurt R. Gregor, Journal of Biological Chemistry	2003	532
Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165 Stephen T. Wrobleski, Ryan Moslin, Shuqun Lin, Journal of Medicinal Chemistry	2019	345
Autoimmune pathways in mice and humans are blocked by pharmacological stabilization of the TYK2 pseudokinase domain James R. Burke, Lihong Cheng, Kathleen M. Gillooly, Science Translational Medicine	2019	268
IKK mediates ischemia-induced neuronal death Oliver Herrmann, Bernd Baumann, Rossana De Lorenzi, Nature Medicine Molecular NeuroscienceNeurophysiologyIschemia-induced Neuronal DeathCell DeathBrain Injury	2005	259
Duration and Intensity of NF-κB Activity Determine the Severity of Endotoxin-Induced Acute Lung Injury M. Brett Everhart, Wei Han, Taylor P. Sherrill, The Journal of Immunology Acute Lung InjuryInflammatory Lung DiseaseLung InflammationInnate Immune SystemImmunology	2006	230
A highly selective inhibitor of IκB kinase, BMS‐345541, blocks both joint inflammation and destruction in collagen‐induced arthritis in mice Kim W. McIntyre, David J. Shuster, Kathleen M. Gillooly, Arthritis & Rheumatism	2003	217
BMS-345541 Targets Inhibitor of κB Kinase and Induces Apoptosis in Melanoma: Involvement of Nuclear Factor κB and Mitochondria Pathways Jinming Yang, Katayoun I. Amiri, James R. Burke, Clinical Cancer Research	2006	165
Caspase-2-Mediated Cleavage of Mdm2 Creates a p53-Induced Positive Feedback Loop Trudy G. Oliver, Etienne Meylan, Gregory P. Chang, Molecular Cell Tumor BiologyCaspase-2-mediated CleavageSignal TransductionMedicineMolecular Biology	2011	161
Discovery of 6-Fluoro-5-(<i>R</i>)-(3-(<i>S</i>)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4<i>H</i>)-yl)-2-methylphenyl)-2-(<i>S</i>)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1<i>H</i>-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton’s Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers Scott H. Watterson, George V. De Lucca, Qing Shi, Journal of Medicinal Chemistry	2016	142
Selectivity Profile of the Tyrosine Kinase 2 Inhibitor Deucravacitinib Compared with Janus Kinase 1/2/3 Inhibitors Anjaneya Chimalakonda, James R. Burke, Lihong Cheng, Dermatology and Therapy	2021	118

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