Kurt R. Gregor

BMS-345541 Is a Highly Selective Inhibitor of IκB Kinase That Binds at an Allosteric Site of the Enzyme and Blocks NF-κB-dependent Transcription in Mice

James R. Burke, Mark A. Pattoli, Kurt R. Gregor et al. · Journal of Biological Chemistry · 2003 · 532 citations · Full text

Collagen and Aggrecan Degradation Is Blocked in Interleukin-1-Treated Cartilage Explants by an Inhibitor of IκB Kinase through Suppression of Metalloproteinase Expression

Mark A. Pattoli, John F. MacMaster, Kurt R. Gregor et al. · Journal of Pharmacology and Experimental Therapeutics · 2005 · 56 citations

Synthesis and biological evaluation of 4-amino derivatives of benzimidazoquinoxaline, benzimidazoquinoline, and benzopyrazoloquinazoline as potent IKK inhibitors

Françis Beaulieu, Carl Ouellet, Edward H. Ruediger et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 53 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Biochemistry +12

Phosphorylation and calcium influx are not sufficient for the activation of cytosolic phospholipase A2 in U937 cells: Requirement for a Giα-type G-protein

James R. Burke, Lynda B. Davern, Kurt R. Gregor et al. · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · 1997 · 42 citations

U937 Cells, Protein Function, Signal Transduction +13

Biologic-like In Vivo Efficacy with Small Molecule Inhibitors of TNFα Identified Using Scaffold Hopping and Structure-Based Drug Design Approaches

Hai‐Yun Xiao, Ning Li, James J.‐W. Duan et al. · Journal of Medicinal Chemistry · 2020 · 39 citations · Full text