G. Paul Savage

Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere

Benjamin A. Chalmers, Hui Xing, Sevan D. Houston et al. · Angewandte Chemie International Edition · 2016 · 187 citations

Pharmacy, Chemistry, Medicinal Chemistry +13

Nonclassical Phenyl Bioisosteres as Effective Replacements in a Series of Novel Open-Source Antimalarials

Edwin G. Tse, Sevan D. Houston, Craig M. Williams et al. · Journal of Medicinal Chemistry · 2020 · 149 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Total Synthesis of the Potent Anticancer Aglaia Metabolites (−)-Silvestrol and (−)-Episilvestrol and the Active Analogue (−)-4′-Desmethoxyepisilvestrol

Timothy E. Adams, Mariana El Sous, Bill C. Hawkins et al. · Journal of the American Chemical Society · 2009 · 89 citations

Pharmacy, Medicinal Chemistry, Oncology +16

Evolution of abiotic cubane chemistries in a nucleic acid aptamer allows selective recognition of a malaria biomarker

Yee‐Wai Cheung, Pascal Röthlisberger, Ariel Méchaly et al. · Proceedings of the National Academy of Sciences · 2020 · 86 citations · Full text

Pharmacy, Biochemistry, Medicinal Chemistry +17

The cubane paradigm in bioactive molecule discovery: further scope, limitations and the cyclooctatetraene complement

Sevan D. Houston, Tyler Fahrenhorst‐Jones, Hui Xing et al. · Organic & Biomolecular Chemistry · 2019 · 76 citations · Full text

Pharmacy, Biochemistry, Medicinal Chemistry +9