Concepedia

Aromatic Isosteric Replacement

Aromatic Isosteric Replacement is a bioisosteric substitution method in which an aromatic ring system is replaced by a structurally or electronically similar non-aromatic moiety to preserve or modulate physicochemical properties and biological activity within a molecule.

15

Publications

557

Citations

112

Authors

25

Institutions

Publications per year

2017–2026

5

Variants

Aromatic Bioisosteric Replacement

Parents

Publications

15

Preclinical evaluation of amino acid prodrugs of novel antitumor 2-(4-amino-3-methylphenyl)benzothiazoles.

Tracey D. Bradshaw, Michael C. Bibby, John A. Double et al. · PubMed · 2002 · 76 citations

, , +16

Recent Advances and Outlook for the Isosteric Replacement of Anilines

Taylor Sodano, Logan A. Combee, Corey R. J. Stephenson · ACS Medicinal Chemistry Letters · 2020 · 70 citations · Full text

, , +15

Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors

Gilda Neves, Ricardo Menegatti, Camila B. Antonio et al. · Bioorganic & Medicinal Chemistry · 2010 · 64 citations · Full text

, , +17

A Comparison of the Physicochemical and Biological Properties of Mirtazapine and Mianserin

J. Kelder, Carel W. Funke, Thus de Boer et al. · Journal of Pharmacy and Pharmacology · 1997 · 56 citations · Full text

, , +15

Exploring the Structure−Activity Relationship of the Ethylamine Portion of 3-Iodothyronamine for Rat and Mouse Trace Amine-Associated Receptor 1

Edwin S. Tan, Motonori Miyakawa, James R. Bunzow et al. · Journal of Medicinal Chemistry · 2007 · 55 citations · Full text

, , +16

1–5 of 15

Authors

112

  1. CL
    Clemens Lamberth

    Syngenta (Switzerland), Switzerland

    1 publications · 47 citations

    1

    h-index

  2. KS
    K Sinozaki

    The University of Osaka, Japan

    1 publications · 15 citations

    1

    h-index

  3. EJ
    Erika J. Gutiérrez-Lara

    Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico

    1 publications · 10 citations

    1

    h-index

  4. RO
    Renan O. Vieira

    Universidade Federal de Goiás, Brazil

    1 publications · 64 citations

    1

    h-index

  5. MS
    Masao Seiki

    Zeria Pharmaceutical (Japan), Japan

    1 publications · 15 citations

    1

    h-index

1–5 of 112

Institutions

25

  1. University of Michigan

    Ann Arbor, United States

    1 h-index

    3 publications

    210 citations

  2. Universidade Federal de Goiás

    Goiânia, Brazil

    1 h-index

    1 publications

    64 citations

  3. Temple University

    Philadelphia, United States

    1 h-index

    3 publications

    78 citations

  4. Instituto Nacional de Pediatria

    Mexico City, Mexico

    1 h-index

    2 publications

    20 citations

  5. Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional

    Mexico City, Mexico

    1 h-index

    2 publications

    20 citations

  6. Universidade Federal do Rio Grande do Sul

    Porto Alegre, Brazil

    1 h-index

    4 publications

    256 citations

  7. ProQuest (United States)

    Ann Arbor, United States

    1 h-index

    1 publications

    39 citations

  8. University of Nottingham

    Nottingham, United Kingdom

    1 h-index

    1 publications

    76 citations

1–8 of 25

Venues

  1. Journal of Medicinal Chemistry

    2 publications · 94 citations

    2

    h-index

  2. Bioorganic & Medicinal Chemistry Letters

    2 publications · 23 citations

    2

    h-index

  3. Bioorganic & Medicinal Chemistry

    1 publications · 64 citations

    1

    h-index

  4. Journal of Pharmacy and Pharmacology

    JPP · 1 publications · 56 citations

    1

    h-index

  5. PubMed

    Repository · 1 publications · 76 citations

    1

    h-index

1–5