Polar Molecular Surface as a Dominating Determinant for Oral Absorption and Brain Penetration of Drugs

J. Kelder, Peter D. J. Grootenhuis, Denis M. Bayada, +2

Pharmaceutical Research

Steroid and G Protein Binding Characteristics of the Seatrout and Human Progestin Membrane Receptor α Subtypes and Their Evolutionary Origins

Peter Thomas, Yefei Pang, Jing Dong, +5

Endocrinology

ImmunologyGynecologyReproductive BiologyCellular PhysiologySeven-transmembrane Domains +20

Use of physicochemical calculation of pKa and CLogP to predict phospholipidosis-inducing potential

Jan-Peter H. T. M. Ploemen, J. Kelder, Theo Hafmans, +4

Experimental and Toxicologic Pathology

Proteinlipid InteractionBiochemistryMedicinePhysiologyBioanalysis +9

A signaling-selective, nanomolar potent allosteric low molecular weight agonist for the human luteinizing hormone receptor

Chris J. van Koppen, Guido J.R. Zaman, C. Marco Timmers, +5

Naunyn-Schmiedeberg s Archives of Pharmacology

Molecular PharmacologyMolecular PhysiologySignal TransductionBiochemistryG Protein-coupled Receptor +7

Comparison between steroid binding to membrane progesterone receptor α (mPRα) and to nuclear progesterone receptor: Correlation with physicochemical properties assessed by comparative molecular field analysis and identification of mPRα-specific agonists

J. Kelder, Rita Azevedo, Yefei Pang, +3

Steroids

Molecular PharmacologyEndocrine MechanismMedicinePhysiologyMprα-specific Agonists +6

Induction of ovulation by a potent, orally active, low molecular weight agonist (Org 43553) of the luteinizing hormone receptor

Ruud van de Lagemaat, C. Marco Timmers, J. Kelder, +3

Human Reproduction

A Comparison of the Physicochemical and Biological Properties of Mirtazapine and Mianserin

J. Kelder, Carel W. Funke, Thus de Boer, +3

Journal of Pharmacy and Pharmacology

Biological PropertiesOrganic ChemistryPharmacotherapyChemistryExperimental Pharmacology +15

Physicochemical Properties and Transport of Steroids Across Caco-2 Cells

Fried Faassen, J. Kelder, Johan Lenders, +2

Pharmaceutical Research

Unique Overlap in the Prerequisites for Thrombin Inhibition and Oral Bioavailability Resulting in Potent Oral Antithrombotics

Anton E.P. Adang, Adrianus P. A. de Man, G.M.T. Vogel, +11

Journal of Medicinal Chemistry

Thrombin Inhibition ConstantPharmacotherapyThrombosisMedicinal ChemistryVenous Thrombosis +19

Effects of steroids with different endocrine profiles on the development, morphology and function of the bursa of Fabricius in chickens

H.A.M. Verheul, E.V. Tittes, J. Kelder, +1

Journal of Steroid Biochemistry

Animal PhysiologyEmbryologyDevelopmental BiologyEndocrine MechanismAnimal Science +9