Peter D. J. Grootenhuis

Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770

Fredrick Van Goor, Sabine Hadidaꝉ, Peter D. J. Grootenhuis et al. · Proceedings of the National Academy of Sciences · 2009 · 1.2K citations · Full text

Medicine, Cell Biology, Pharmacology +17

Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809

Fredrick Van Goor, Sabine Hadidaꝉ, Peter D. J. Grootenhuis et al. · Proceedings of the National Academy of Sciences · 2011 · 1.1K citations · Full text

Medicine, Molecular Biology, Pharmacology +13

Polar Molecular Surface as a Dominating Determinant for Oral Absorption and Brain Penetration of Drugs

J. Kelder, Peter D. J. Grootenhuis, Denis M. Bayada et al. · Pharmaceutical Research · 1999 · 799 citations

Pharmacy, Pharmacokinetics, Pharmacology +13

Rescue of ΔF508-CFTR trafficking and gating in human cystic fibrosis airway primary cultures by small molecules

Fredrick Van Goor, Kimberly Straley, Dong Cao et al. · American Journal of Physiology-Lung Cellular and Molecular Physiology · 2006 · 502 citations

Life Sciences, Cell Biology, Molecular Biology +17

The intact and cleaved human antithrombin III complex as a model for serpin–proteinase interactions

Herman Schreuder, Bijtske de Boer, R. Dijkema et al. · Nature Structural & Molecular Biology · 1994 · 280 citations

Life Sciences, Biochemistry, Molecular Biology +13