Concepedia

Polar Molecular Surface as a Dominating Determinant for Oral Absorption and Brain Penetration of Drugs

J. Kelder, Peter D. J. Grootenhuis, Denis M. Bayada, L. P. C. Delbressine, Jan‐Peter Ploemen

Pharmaceutical Research · 1999 · 799 citations · 8 references

DOI

Concepts

References

8

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Christopher A. Lipinski, Franco Lombardo, Beryl W. Dominy et al. · Advanced Drug Delivery Reviews · 1997 · 11.2K citations

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Polar Molecular Surface Properties Predict the Intestinal Absorption of Drugs in Humans

Katrin Palm, Patric Stenberg, Kristina Luthman et al. · Pharmaceutical Research · 1997 · 751 citations

, , +14

Development of a new physicochemical model for brain penetration and its application to the design of centrally acting H2 receptor histamine antagonists

Rodney C. Young, Robert Cameron Mitchell, Thomas H. Brown et al. · Journal of Medicinal Chemistry · 1988 · 522 citations

, , +15

Hydrogen Bonding. 33. Factors That Influence the Distribution of Solutes between Blood and Brain

Michael H. Abraham, Harpreet S. Chadha, Robert C. Mitchell · Journal of Pharmaceutical Sciences · 1994 · 301 citations

, , +10

Computation of Brain−Blood Partitioning of Organic Solutes via Free Energy Calculations

Franco Lombardo, James F. Blake, William Curatolo · Journal of Medicinal Chemistry · 1996 · 198 citations

, , +16