Concepedia

Nonclassical Bioisosterism

Nonclassical Bioisosterism is a form of bioisosterism in which structurally diverse substituents or scaffolds exhibit similar biological activity despite lacking the conventional structural or electronic similarities characteristic of classical bioisosteres.

7

Publications

714

Citations

71

Authors

14

Institutions

Publications per year

2017–2026

2

Variants

Non-classical Bioisosterism

Parents

Publications

7

Application of the Bicyclo[1.1.1]pentane Motif as a Nonclassical Phenyl Ring Bioisostere in the Design of a Potent and Orally Active γ-Secretase Inhibitor

Antonia F. Stepan, Chakrapani Subramanyam, Ivan Efremov et al. · Journal of Medicinal Chemistry · 2012 · 446 citations · Full text

, , +17

Nonclassical Phenyl Bioisosteres as Effective Replacements in a Series of Novel Open-Source Antimalarials

Edwin G. Tse, Sevan D. Houston, Craig M. Williams et al. · Journal of Medicinal Chemistry · 2020 · 149 citations · Full text

, , +17

Design and synthesis of novel triazole antifungal derivatives by structure-based bioisosterism

Chunquan Sheng, Xiaoying Che, Wenya Wang et al. · European Journal of Medicinal Chemistry · 2011 · 52 citations

, , +14

Hydroxy-1,2,5-oxadiazolyl Moiety as Bioisoster of the Carboxy Function. Synthesis, Ionization Constants, and Pharmacological Characterization of γ-Aminobutyric Acid (GABA) Related Compounds

Marco L. Lolli, Suzanne L. Hansen, Barbara Rolando et al. · Journal of Medicinal Chemistry · 2006 · 27 citations

, , +17

Identification of Bioisosteric Substituents by a Deep Neural Network

Peter Ertl · Journal of Chemical Information and Modeling · 2020 · 15 citations

, , +17

1–5 of 7

Authors

71

  1. AA
    Alya A. Arabi

    United Arab Emirates University, United Arab Emirates

    2 publications · 27 citations

    2

    h-index

  2. ME
    Michael E. Green

    City College of New York, United States

    1 publications · 446 citations

    1

    h-index

  3. SC
    S.H. Capetta

    Pfizer (United States), United States

    1 publications · 446 citations

    1

    h-index

  4. OM
    Orla Miller Larsen

    University of Turin, Italy

    1 publications · 27 citations

    1

    h-index

  5. KK
    Karsten K. Madsen

    University of Copenhagen, Denmark

    1 publications · 27 citations

    1

    h-index

1–5 of 71

Institutions

14

  1. Pfizer (United States)

    New York, United States

    2 h-index

    30 publications

    12.5K citations

  2. Zayed University

    Abu Dhabi, United Arab Emirates

    2 h-index

    2 publications

    27 citations

  3. Shandong University

    Jinan, China

    1 h-index

    9 publications

    117 citations

  4. Second Military Medical University

    Shanghai, China

    1 h-index

    8 publications

    416 citations

  5. The University of Queensland

    Brisbane, Australia

    1 h-index

    2 publications

    298 citations

  6. KU Leuven

    Leuven, Belgium

    1 h-index

    3 publications

    39 citations

  7. University of Turin

    Turin, Italy

    1 h-index

    11 publications

    297 citations

  8. University of Dundee

    Dundee, United Kingdom

    1 h-index

    2 publications

    298 citations

1–8 of 14

Venues

  1. Journal of Medicinal Chemistry

    3 publications · 622 citations

    3

    h-index

  2. Future Medicinal Chemistry

    FMC · 2 publications · 27 citations

    2

    h-index

  3. Bioorganic & Medicinal Chemistry

    1 publications · 13 citations

    1

    h-index

  4. European Journal of Medicinal Chemistry

    1 publications · 52 citations

    1

    h-index

  5. Journal of Chemical Information and Modeling

    JCIM · 1 publications · 15 citations

1–5