Ivan Efremov

Application of the Bicyclo[1.1.1]pentane Motif as a Nonclassical Phenyl Ring Bioisostere in the Design of a Potent and Orally Active γ-Secretase Inhibitor

Antonia F. Stepan, Chakrapani Subramanyam, Ivan Efremov et al. · Journal of Medicinal Chemistry · 2012 · 446 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( <i>S</i> )-2,2-Difluorocyclopropyl)((1 <i>R</i> ,5 <i>S</i> )-3-(2-((1-methyl-1 <i>H</i> -pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841)

Andrew Fensome, Catherine M. Ambler, Eric P. Arnold et al. · Journal of Medicinal Chemistry · 2018 · 174 citations · Full text

Life Sciences, Immunology, Pharmacology +17

A Convenient Method for Removing All Highly-Colored Byproducts Generated during Olefin Metathesis Reactions

Leo A. Paquette, Jeffrey D. Schloss, Ivan Efremov et al. · Organic Letters · 2000 · 147 citations

Natural Sciences, Chemistry, Catalysis +12

Metabolism-Directed Design of Oxetane-Containing Arylsulfonamide Derivatives as γ-Secretase Inhibitors

Antonia F. Stepan, Kapil Karki, W. Scott McDonald et al. · Journal of Medicinal Chemistry · 2011 · 106 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Impaired β-arrestin recruitment and reduced desensitization by non-catechol agonists of the D1 dopamine receptor

David Gray, John Allen, Scot Mente et al. · Nature Communications · 2018 · 97 citations · Full text

Medicine, Neuroscience, Pharmacology +15