Catherine M. Ambler

Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( <i>S</i> )-2,2-Difluorocyclopropyl)((1 <i>R</i> ,5 <i>S</i> )-3-(2-((1-methyl-1 <i>H</i> -pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841)

Andrew Fensome, Catherine M. Ambler, Eric P. Arnold et al. · Journal of Medicinal Chemistry · 2018 · 174 citations · Full text

Life Sciences, Immunology, Pharmacology +17

Discovery of Clinical Candidate 1-{[(2 <i>S</i> ,3 <i>S</i> ,4 <i>S</i> )-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design

Katherine L. Lee, Catherine M. Ambler, David R. Anderson et al. · Journal of Medicinal Chemistry · 2017 · 145 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

High temperature transport properties of polyphosphazene membranes for direct methanol fuel cells

Xiangyang Zhou, Jamie Weston, Elena Chalkova et al. · Electrochimica Acta · 2003 · 117 citations

Engineering, Chemical Engineering, Materials Science +16

Synthesis of Polyphosphazenes with Sulfonimide Side Groups

Michael Hofmann, Catherine M. Ambler, Andrew E. Maher et al. · Macromolecules · 2002 · 106 citations

Natural Sciences, Chemical Engineering, Chemistry +5

Phenylphosphonic Acid Functionalized Poly[aryloxyphosphazenes]

Harry R. Allcock, Michael Hofmann, Catherine M. Ambler et al. · Macromolecules · 2002 · 100 citations

Natural Sciences, Chemical Engineering, Chemistry +17