Andrew Fensome

Design, Synthesis, and SAR of New Pyrrole-Oxindole Progesterone Receptor Modulators Leading to 5-(7-Fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1<i>H</i>-indol-5-yl)-1-methyl-1<i>H</i>-pyrrole-2-carbonitrile (WAY-255348)

Andrew Fensome, William R. Adams, Andrea L. Adams et al. · Journal of Medicinal Chemistry · 2008 · 198 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( <i>S</i> )-2,2-Difluorocyclopropyl)((1 <i>R</i> ,5 <i>S</i> )-3-(2-((1-methyl-1 <i>H</i> -pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841)

Andrew Fensome, Catherine M. Ambler, Eric P. Arnold et al. · Journal of Medicinal Chemistry · 2018 · 174 citations · Full text

Life Sciences, Immunology, Pharmacology +17

Potent nonsteroidal progesterone receptor agonists: Synthesis and SAR study of 6-aryl benzoxazines

Puwen Zhang, Eugene A. Terefenko, Andrew Fensome et al. · Bioorganic & Medicinal Chemistry Letters · 2002 · 117 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11

6-Aryl-1,4-dihydro-benzo[<i>d</i>][1,3]oxazin- 2-ones:  A Novel Class of Potent, Selective, and Orally Active Nonsteroidal Progesterone Receptor Antagonists

Puwen Zhang, Eugene A. Terefenko, Andrew Fensome et al. · Journal of Medicinal Chemistry · 2002 · 106 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a TYK2/JAK1 Inhibitor (PF‐06700841) in Healthy Subjects and Patients With Plaque Psoriasis

Christopher Banfield, Matthew Scaramozza, Weidong Zhang et al. · The Journal of Clinical Pharmacology · 2017 · 94 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +12