Kapil Karki

Application of the Bicyclo[1.1.1]pentane Motif as a Nonclassical Phenyl Ring Bioisostere in the Design of a Potent and Orally Active γ-Secretase Inhibitor

Antonia F. Stepan, Chakrapani Subramanyam, Ivan Efremov et al. · Journal of Medicinal Chemistry · 2012 · 412 citations · Full text

Metabolism-Directed Design of Oxetane-Containing Arylsulfonamide Derivatives as γ-Secretase Inhibitors

Antonia F. Stepan, Kapil Karki, W. Scott McDonald et al. · Journal of Medicinal Chemistry · 2011 · 106 citations · Full text

Chemical Biology, Experimental Pharmacology, Pharmaceutical Chemistry +16

Discovery of the pan-genotypic hepatitis C virus NS3/4A protease inhibitor voxilaprevir (GS-9857): A component of Vosevi®

James G. Taylor, Sheila Zipfel, Kyla Ramey et al. · Bioorganic & Medicinal Chemistry Letters · 2019 · 83 citations

Molecular Virology, Viral Hepatitis, Immunology +6

Discovery of a Potent and Orally Bioavailable Cyclophilin Inhibitor Derived from the Sanglifehrin Macrocycle

Richard L. Mackman, Victoria A. Steadman, David K. Dean et al. · Journal of Medicinal Chemistry · 2018 · 75 citations · Full text

Designing glucokinase activators with reduced hypoglycemia risk: discovery of N,N-dimethyl-5-(2-methyl-6-((5-methylpyrazin-2-yl)-carbamoyl)benzofuran-4-yloxy)pyrimidine-2-carboxamide as a clinical candidate for the treatment of type 2 diabetes mellitus

Jeffrey A. Pfefferkorn, Angel Guzmán-Pérez, Peter J. Oates et al. · MedChemComm · 2011 · 68 citations