Iodine(V) Reagents in Organic Synthesis. Part 3. New Routes to Heterocyclic Compounds via <i>o</i>-Iodoxybenzoic Acid-Mediated Cyclizations:  Generality, Scope, and Mechanism

K. C. Nicolaou, Phil S. Baran, Yong‐Li Zhong, +4

Journal of the American Chemical Society

Novel IBX-Mediated Processes for the Synthesis of Amino Sugars and Libraries Thereof

K. C. Nicolaou, Phil S. Baran, Yong‐Li Zhong, +1

Angewandte Chemie International Edition

BiosynthesisBioorganic ChemistryDiverse ArraysBiochemistryLibraries Thereof +13

Discovery of 3-Cyclopropylmethyl-7-(4-phenylpiperidin-1-yl)-8-trifluoromethyl[1,2,4]triazolo[4,3-<i>a</i>]pyridine (JNJ-42153605): A Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor

José M. Cid, Gary Tresadern, Juan A. Vega, +16

Journal of Medicinal Chemistry

Rem Sleep StatePharmacotherapyMglu2 Receptor PamsExperimental PharmacologyPre-clinical Pharmacology +20

Scaffold hopping from pyridones to imidazo[1,2-a]pyridines. New positive allosteric modulators of metabotropic glutamate 2 receptor

Gary Tresadern, José M. Cid, Gregor J. Macdonald, +9

Bioorganic & Medicinal Chemistry Letters

Scaffold HoppingMetabotropic Glutamate 2BiochemistryMedicineFunctional Selectivity +5

A new approach to the synthesis of 2-aminoimidazo[1,2-a]pyridine derivatives through microwave-assisted N-alkylation of 2-halopyridines

Juan A. Vega, Juan J. Vaquero, Julio Álvarez‐Buílla, +2

Tetrahedron

Microwave-assisted N-alkylationNew ApproachOrganic ChemistryChemistryHalogenation +1

Imidazo[1,2-<i>a</i>]pyridines: Orally Active Positive Allosteric Modulators of the Metabotropic Glutamate 2 Receptor

Andrés A. Trabanco, Gary Tresadern, Gregor J. Macdonald, +14

Journal of Medicinal Chemistry

PharmacotherapyMolecular PharmacologyMedicinal ChemistryAdvanced LeadsSleep +15

Novel IBX-Mediated Processes for the Synthesis of Amino Sugars and Libraries Thereof

K. C. Nicolaou, Phil S. Baran, Yong‐Li Zhong, +1

Angewandte Chemie

Bioorganic ChemistryDie AnellierungChemical BiologyEnzymatic ModificationBeispiel Siehe Schema +14

Discovery of 1-Butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1 <i>H</i> )-pyridone (JNJ-40411813): A Novel Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor

José M. Cid, Gary Tresadern, Guillaume Duvey, +20

Journal of Medicinal Chemistry

Fluorous-Tagged Carbamates for the Pd-Catalyzed Amination of Aryl Halides

Andrés A. Trabanco, Juan A. Vega, Manuel Fernández

The Journal of Organic Chemistry

Combinatorial ChemistryEngineeringFluorous Separation TechniquesCatalytic SynthesisFluorous Synthesis +9

Rational design and synthesis of aminopiperazinones as β-secretase (BACE) inhibitors

Gary Tresadern, Francisca Delgado, Óscar Delgado, +9

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryRational DesignNatural SciencesMedicine +6