Edward J. Brnardic

Maximizing Diversity from a Kinase Screen: Identification of Novel and Selective pan-Trk Inhibitors for Chronic Pain

Shawn J. Stachel, John M. Sanders, Darrell A. Henze et al. · Journal of Medicinal Chemistry · 2014 · 60 citations · Full text

Small Molecule Inhibitors, Drug Target, Pain Medicine +22

Identification and in Vivo Evaluation of Liver X Receptor β-Selective Agonists for the Potential Treatment of Alzheimer’s Disease

Shawn J. Stachel, Celina Zerbinatti, Michael T. Rudd et al. · Journal of Medicinal Chemistry · 2016 · 47 citations · Full text

Pharmacotherapy, Agonist Series, Alzheimer ’ +22

3-(Indol-2-yl)indazoles as Chek1 kinase inhibitors: Optimization of potency and selectivity via substitution at C6

Mark E. Fraley, Justin T. Steen, Edward J. Brnardic et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 46 citations · Full text

Medicinal Chemistry, Medicine, Drug Discovery +9

Optimization of a pyrazoloquinolinone class of Chk1 kinase inhibitors

Edward J. Brnardic, R. M. Garbaccio, Mark E. Fraley et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 44 citations · Full text

Medicinal Chemistry, Biochemistry, Medicine +6

3-Aryl-5-phenoxymethyl-1,3-oxazolidin-2-ones as positive allosteric modulators of mGluR2 for the treatment of schizophrenia: Hit-to-lead efforts

Edward J. Brnardic, Mark E. Fraley, R. M. Garbaccio et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 40 citations · Full text

Medicinal Chemistry, Psychoactive Drug, Psychiatry +11