R. M. Garbaccio

Kinesin Spindle Protein (KSP) Inhibitors. 9. Discovery of (2<i>S</i>)-4-(2,5-Difluorophenyl)-<i>N</i>-[(3<i>R</i>,4<i>S</i>)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-<i>N</i>-methyl-2-phenyl-2,5-dihydro-1<i>H</i>-pyrrole-1-carboxamide (MK-0731) for the Treatment of Taxane-Refractory Cancer

Christopher D. Cox, Paul J. Coleman, Michael J. Breslin et al. · Journal of Medicinal Chemistry · 2008 · 156 citations · Full text

Medicine, Oncology, Pharmacology +13

Concise Asymmetric Syntheses of Radicicol and Monocillin I

R. M. Garbaccio, Shawn J. Stachel, Daniel K. Baeschlin et al. · Journal of the American Chemical Society · 2001 · 144 citations

Pharmacy, Medicinal Chemistry, Pharmacology +16

Shape-Dependent Catalysis:  Insights into the Source of Catalysis for the CC-1065 and Duocarmycin DNA Alkylation Reaction

Dale L. Boger, R. M. Garbaccio · Accounts of Chemical Research · 1999 · 143 citations

Pharmacy, Biochemistry, Chemistry +10

Discovery of Pyrophosphate Diesters as Tunable, Soluble, and Bioorthogonal Linkers for Site-Specific Antibody–Drug Conjugates

Jeffrey C. Kern, Mark T. Cancilla, Deborah Dooney et al. · Journal of the American Chemical Society · 2016 · 141 citations

Pharmacy, Pharmaceutics, Pharmacology +17

Orally Bioavailable Macrocyclic Peptide That Inhibits Binding of PCSK9 to the Low Density Lipoprotein Receptor

Douglas G. Johns, Louis‐Charles Campeau, Puja Banka et al. · Circulation · 2023 · 141 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17