Jeffrey C. Kern

Design, Synthesis, and SAR of New Pyrrole-Oxindole Progesterone Receptor Modulators Leading to 5-(7-Fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1<i>H</i>-indol-5-yl)-1-methyl-1<i>H</i>-pyrrole-2-carbonitrile (WAY-255348)

Andrew Fensome, William R. Adams, Andrea L. Adams et al. · Journal of Medicinal Chemistry · 2008 · 196 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Pr Antagonist +13

Discovery of Pyrophosphate Diesters as Tunable, Soluble, and Bioorthogonal Linkers for Site-Specific Antibody–Drug Conjugates

Jeffrey C. Kern, Mark T. Cancilla, Deborah Dooney et al. · Journal of the American Chemical Society · 2016 · 136 citations

A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation

Peter V.N. Bodine, Barbara Stauffer, Helga Ponce‐de‐Leon et al. · Bone · 2009 · 124 citations

Sclerostin, Signal Transduction, Bone Morphogenic Protein +12

Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation

Chuan Hong, Noel Byrne, Beata Zamlynny et al. · Nature Communications · 2021 · 116 citations · Full text

Novel Phosphate Modified Cathepsin B Linkers: Improving Aqueous Solubility and Enhancing Payload Scope of ADCs

Jeffrey C. Kern, Deborah Dooney, Rena Zhang et al. · Bioconjugate Chemistry · 2016 · 89 citations