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3-Aryl-5-phenoxymethyl-1,3-oxazolidin-2-ones as positive allosteric modulators of mGluR2 for the treatment of schizophrenia: Hit-to-lead efforts

Edward J. Brnardic, Mark E. Fraley, R. M. Garbaccio, M. E. Layton, John M. Sanders, Chris Culberson, Marlene A. Jacobson, Brian C. Magliaro, Pete H. Hutson, Julie A. O’Brien,

Bioorganic & Medicinal Chemistry Letters · 2010 · 40 citations · 12 references

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References

12

Effectiveness of Antipsychotic Drugs in Patients with Chronic Schizophrenia

Jeffrey A. Lieberman, T. Scott Stroup, Joseph P. McEvoy et al. · New England Journal of Medicine · 2005 · 5.9K citations · Full text

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The de Facto US Mental and Addictive Disorders Service System

Darrel A. Regier · Archives of General Psychiatry · 1993 · 2K citations

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Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial

Sandeep T. Patil, Lu Zhang, Ferenc Martényi et al. · Nature Medicine · 2007 · 1K citations

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Reversal of Phencyclidine Effects by a Group II Metabotropic Glutamate Receptor Agonist in Rats

Bita Moghaddam, Barbara W. Adams · Science · 1998 · 1K citations

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Unveiling the Functions of Presynaptic Metabotropic Glutamate Receptors in the Central Nervous System

D D Schoepp · Journal of Pharmacology and Experimental Therapeutics · 2001 · 690 citations

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