Brian C. Magliaro

The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents

P.H. Hutson, Eleftheria N. Finger, Brian C. Magliaro et al. · Neuropharmacology · 2011 · 139 citations

Life Sciences, Neuroscience, Pharmacology +16

Mechanism based neurotoxicity of mGlu5 positive allosteric modulators – Development challenges for a promising novel antipsychotic target

Sophie Parmentier‐Batteur, Peter H. Hutson, Karsten Menzel et al. · Neuropharmacology · 2013 · 94 citations

Medicine, Neuroscience, Pharmacology +15

Clozapine protects PC-12 cells from death due to oxidative stress induced by hydrogen peroxide via a cell-type specific mechanism involving inhibition of extracellular signal-regulated kinase phosphorylation

Brian C. Magliaro, Colin J. Saldanha · Brain Research · 2009 · 62 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +17

Induction of matrix metalloproteinase, cytokines and chemokines in rat cortical astrocytes exposed to plasminogen activators

Sun-Ryung Lee, Shuzhen Guo, Robert H. Scannevin et al. · Neuroscience Letters · 2007 · 61 citations

Medicine, Neurobiology, Neuroscience +14

3-Aryl-5-phenoxymethyl-1,3-oxazolidin-2-ones as positive allosteric modulators of mGluR2 for the treatment of schizophrenia: Hit-to-lead efforts

Edward J. Brnardic, Mark E. Fraley, R. M. Garbaccio et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 40 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13