P.H. Hutson

The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents

P.H. Hutson, Eleftheria N. Finger, Brian C. Magliaro et al. · Neuropharmacology · 2011 · 139 citations

Life Sciences, Neuroscience, Pharmacology +16

Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA-966 is a potent gamma-butyrolactone-like sedative.

L. Singh, Angus E. Donald, Alan C. Foster et al. · Proceedings of the National Academy of Sciences · 1990 · 136 citations

Medicine, Neuroscience, Pharmacology +15

The glycine/NMDA receptor antagonist, R‐(+)‐HA‐966, blocks activation of the mesolimbic dopaminergic system induced by phencyclidine and dizocilpine (MK‐801) in rodents

Linda J. Bristow, P.H. Hutson, L. Thorn et al. · British Journal of Pharmacology · 1993 · 94 citations · Full text

Medicine, Neuroscience, Pharmacology +15

Novel Selective Compounds for the Investigation of Imidazoline Receptors^a

Alan L. Hudson, Rhianon Gough, Robin J. Tyacke et al. · Annals of the New York Academy of Sciences · 1999 · 78 citations

Medicine, Medicinal Chemistry, Pharmacology +9

Glucocorticoid modulation of tryptophan hydroxylase-2 protein in raphe nuclei and 5-hydroxytryptophan concentrations in frontal cortex of C57/Bl6 mice

J A Clark, Rosemarie B. Flick, L-Y Pai et al. · Molecular Psychiatry · 2007 · 76 citations

Life Sciences, Neurobiology, Neuroscience +14