Concepedia

The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents

P.H. Hutson, Eleftheria N. Finger, Brian C. Magliaro, Sean M. Smith, Antonella Converso, Philip E.J. Sanderson, Deborra Mullins, Lynn A. Hyde, Benjamin K. Eschle, Zara Turnbull,

Neuropharmacology · 2011 · 139 citations · 37 references

DOI

Concepts

References

37

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, , +12

Moving beyond Rules: The Development of a Central Nervous System Multiparameter Optimization (CNS MPO) Approach To Enable Alignment of Druglike Properties

Travis T. Wager, Xinjun Hou, Patrick R. Verhoest et al. · ACS Chemical Neuroscience · 2010 · 1K citations

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Quantitative comparison of phosphodiesterase mRNA distribution in human brain and peripheral tissues

Viktor Lakics, Eric Karran, Frank Boess · Neuropharmacology · 2010 · 456 citations

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Role of guanylyl cyclase and cGMP-dependent protein kinase in long-term potentiation

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, , +12

Genetic and Pharmacological Evidence for a Novel, Intermediate Phase of Long-Term Potentiation Suppressed by Calcineurin

Danny G. Winder, Isabelle M. Mansuy, Mona Osman et al. · Cell · 1998 · 353 citations · Full text