The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents

References

Page 1

	Year	Citations
Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity Hey‐Kyoung Lee, Michaela Barbarosie, Kimihiko Kameyama, Nature Synaptic PlasticityMolecular PhysiologySignal TransductionNeurophysiologySynaptic Transmission	2000	1.1K
Moving beyond Rules: The Development of a Central Nervous System Multiparameter Optimization (CNS MPO) Approach To Enable Alignment of Druglike Properties Travis T. Wager, Xinjun Hou, Patrick R. Verhoest, ACS Chemical Neuroscience Pharmaceutical ScienceDrug TargetEngineeringPfizer Cns CandidatesSystem Pharmacology	2010	1K
Quantitative comparison of phosphodiesterase mRNA distribution in human brain and peripheral tissues Viktor Lakics, Eric Karran, Frank Boess Neuropharmacology NeurophysiologyNeuroanatomyPhysiologyNeurophysiological BiomarkersNeurochemical Biomarkers	2010	456
Role of guanylyl cyclase and cGMP-dependent protein kinase in long-term potentiation Min Zhuo, Yinghe Hu, Carsten Schultz, Nature Cgmp-dependent Protein KinaseMolecular PharmacologyMolecular PhysiologySignal TransductionMolecular Pathway	1994	441
Genetic and Pharmacological Evidence for a Novel, Intermediate Phase of Long-Term Potentiation Suppressed by Calcineurin Danny G. Winder, Isabelle M. Mansuy, Mona Osman, Cell	1998	353
Isolation and Characterization of PDE9A, a Novel Human cGMP-specific Phosphodiesterase Douglas A. Fisher, James F. Smith, Joann S. Pillar, Journal of Biological Chemistry	1998	341
Inhibition of phosphodiesterase 2 increases neuronal cGMP, synaptic plasticity and memory performance Frank Boess, Martin Hendrix, F. Josef van der Staay, Neuropharmacology Phosphodiesterase 2Synaptic PlasticityNeurophysiologySynaptic TransmissionPhysiology	2004	324
Phosphodiesterase 5 Inhibition Improves Synaptic Function, Memory, and Amyloid- Load in an Alzheimer's Disease Mouse Model Daniela Puzzo, Anna Staniszewski, Shijie Deng, Journal of Neuroscience	2009	319
Learning‐related patterns of CA1 spike trains parallel stimulation parameters optimal for inducing hippocampal long‐term potentiation Tim Otto, Howard Eichenbaum, Cynthia G. Wible, Hippocampus	1991	301
Genetic Differences in Response to Novelty and Spatial Memory Using a Two-Trial Recognition Task in Mice F. Dellu, Angelo Contarino, H. Simon, Neurobiology of Learning and Memory Genetic DifferencesBehavioral SciencesCognitive ScienceBehavioral NeuroscienceMemory	2000	295

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