Travis T. Wager

Moving beyond Rules: The Development of a Central Nervous System Multiparameter Optimization (CNS MPO) Approach To Enable Alignment of Druglike Properties

Travis T. Wager, Xinjun Hou, Patrick R. Verhoest et al. · ACS Chemical Neuroscience · 2010 · 1K citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Physiochemical drug properties associated with in vivo toxicological outcomes

Jason D. Hughes, Julian Blagg, David A. Price et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 973 citations

Pharmacy, Pharmacology, Toxicology +14

Central Nervous System Multiparameter Optimization Desirability: Application in Drug Discovery

Travis T. Wager, Xinjun Hou, Patrick R. Verhoest et al. · ACS Chemical Neuroscience · 2016 · 605 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11

Defining Desirable Central Nervous System Drug Space through the Alignment of Molecular Properties, in Vitro ADME, and Safety Attributes

Travis T. Wager, Ramalakshmi Y. Chandrasekaran, Xinjun Hou et al. · ACS Chemical Neuroscience · 2010 · 483 citations

Pharmacy, Medicinal Chemistry, Pharmacology +16

Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes

Qing‐Jun Meng, Elizabeth S. Maywood, David A. Bechtold et al. · Proceedings of the National Academy of Sciences · 2010 · 262 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17