Concepedia

Physiochemical drug properties associated with in vivo toxicological outcomes

Jason D. Hughes, Julian Blagg, David A. Price, Simon Bailey, Gary DeCrescenzo, Rajesh Devraj, Edmund L. Ellsworth, Yvette M. Fobian, Michael E. Gibbs, Richard W. Gilles,

Bioorganic & Medicinal Chemistry Letters · 2008 · 973 citations · 8 references

DOI

Concepts

References

8

Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties

Peter Ertl, Bernhard Rohde, Paul M. Selzer · Journal of Medicinal Chemistry · 2000 · 3K citations

, , +15

Predicting ADME properties and side effects: the BioPrint approach.

Cecile M. Krejsa, Dragos Horvath, Sherri L Rogalski et al. · PubMed · 2003 · 179 citations

, , +17

Modeling Promiscuity Based on in vitro Safety Pharmacology Profiling Data

Jacques Hamon, Bernard Faller, Steven Whitebread et al. · ChemMedChem · 2007 · 177 citations

, , +13

PDE4 inhibitors induce emesis in ferrets via a noradrenergic pathway

Annette Robichaud, Chantal Savoie, Panagiota B. Stamatiou et al. · Neuropharmacology · 2001 · 131 citations

, , +14

Pharmacokinetics and Metabolism in Drug Design

European Journal of Medicinal Chemistry · 2003 · 113 citations

, , +7